Puromycin and cycloheximide: different effects on hippocampal electrical activity.
نویسندگان
چکیده
Abstract. Mice were injected in the temporal region of the brain with cycloheximide or puromycin; both agents markedly inhibit protein synthesis in the brain. Recordings of electrical activity were made in the hippocampal region 5 hours after injection of these drugs. The amplitude and frequency observed in records from mice injected with cycloheximide were indistinguishable from those injected with saline alone. Records from puromycin-injected mice were strikingly abnormal. This finding may contribute to the differences in behavioral effects of intracerebral injections of the two inhibitors of protein synthesis studied.
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ورودعنوان ژورنال:
- Science
دوره 154 3756 شماره
صفحات -
تاریخ انتشار 1966